2020–21 Clemson Tigers women's basketball team

The Tigers were led by third year head coach Amanda Butler.

The Tigers, members of the Atlantic Coast Conference, played their home games at Littlejohn Coliseum.

In the ACC tournament, they defeated Notre Dame in the second round before losing to Georgia Tech in the quarterfinals.

They lost to Boston College in the second round of the ACC tournament.

The NCAA tournament and WNIT were cancelled due to the COVID-19 outbreak.