The 2022–23 Clemson Tigers women's basketball team represented Clemson University during the 2022–23 college basketball season.

The Tigers were led by fifth year head coach Amanda Butler.

The Tigers, members of the Atlantic Coast Conference, played their home games at Littlejohn Coliseum.

The Tigers defeated High Point in the First Round and Auburn in the Second Round before losing to Florida in the Super 16 to end their season.

In the ACC tournament, they defeated twelfth seeded Syracuse in the First Round before losing to fifth seed Virginia Tech in the Second Round.