[32] On July 1, the regional tournament was officially announced as a 'pre-season event' with Detroit City taking part alongside three other association members.

[36] The format consisted of a regionalized East/West divisional competition beginning 8 August, with Detroit playing in the Eastern Conference, and a single-location tournament to be held 21 September through 2 October, resulting in a single Fall champion.

Source: Match reports Detroit City FC hosted the entirety of the 2020-21 NISA Fall Playoffs at Keyworth Stadium.

[37] Bold = winner* = after extra time, ( ) = penalty shootout scoreSource: nisaofficial.com The Spring season began on April 13, 2021, with a bubble tournament named Legends Cup and hosted by Chattanooga FC, with the winner gaining entry into the Spring 2021 Final.

The best team at the end of the group stage qualifies directly to the Legends Cup final, while the second and third seeds will play a semifinal game to determine the second finalist.