The 2020–21 season was MŠK Žilina's 113th season in existence and the club's 24th consecutive season in the top flight of Slovak football.
In addition to the domestic league, Žilina participated in this season's edition of the Slovak Cup and the UEFA Europa League.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Players may hold more than one non-FIFA nationality.
Source: Competitions