The 2020–21 NC State Wolfpack women's basketball team represented North Carolina State University during the 2020–21 NCAA Division I women's basketball season.

The Wolfpack were led by eighth year head coach Wes Moore and played their home games at Reynolds Coliseum as members of the Atlantic Coast Conference.

It was NC State's sixth title in school history.

They advanced to the finals of the ACC women's tournament where they defeated Florida State to win the ACC Tournament for the first time since 1991.

As winners of the conference tournament, the Wolfpack received the automatic bid to the 2020 NCAA Division I women's basketball tournament, however, due to the COVID-19 pandemic, the NCAA Tournament was canceled on March 12, 2020.