In addition to the domestic league, Lazio participated in this season's editions of the Coppa Italia and also participated in the UEFA Champions League.

The season covered the period from 2 August 2020 to 30 June 2021.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.