The Cavaliers were led by third year head coach Tina Thompson, and played their home games at John Paul Jones Arena as members the Atlantic Coast Conference.

On January 14, 2021, it was announced that the team would end their season due to COVID-19 concerns.

[1] Virginia was the second team in the Atlantic Coast Conference to suspend their season, after Duke did so on December 25, 2020.

As the ninth seed in the ACC tournament, they lost to Syracuse in Second Round.

The NCAA tournament and WNIT were cancelled due to the COVID-19 outbreak.