If the aggregate score was level, the second-leg match would go straight to the penalty shoot-out to determine the winners.
[2] The draw for the round of 16 was held on 1 October 2020, 11:30 at CBF headquarters in Rio de Janeiro.
[3] The 16 qualified teams were drawn in a single group (CBF ranking shown in parentheses).
The draw for the quarter-finals was held on 6 November 2020, 11:30 at CBF headquarters in Rio de Janeiro.
The draw to determine the home-and-away teams for both legs were held on 24 November 2020, 15:00 at CBF headquarters in Rio de Janeiro.
The draw to determine the home-and-away teams for both legs was held on 14 January 2021, 11:30 at CBF headquarters in Rio de Janeiro.