[6] The matches were played in the José Amalfitani Stadium in Buenos Aires and the Estadio Nuevo Francisco Urbano in Morón.

[26] Few days before the beginning of the tournament, the Uruguayan referee Claudia Umpiérrez was replaced by Anahí Fernández.

[27] The draw for the tournament was held on 23 February 2021, 12:00 PYST (UTC−3), at the CONMEBOL Convention Centre in Luque, Paraguay.

The host country additional team River Plate were automatically seeded into Pot 3, while the four additional teams from associations with the best historical performance were automatically seeded into Pot 4.

The remaining teams were seeded based on the results of their association in the 2019 Copa Libertadores Femenina.