The 2020 season was Santa Cruz's 107th season in the club's history.

[3] Santa Cruz competed in the Campeonato Pernambucano,[4] Copa do Brasil,[5] Série C, Copa do Brasil,[6] and Copa do Nordeste.

[7] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Source: Santa Cruz official website (c) Indicates the caretaker manager