Fabio Quartararo was the defending MotoGP race winner who aimed for his second consecutive Grand Prix win, having won the previous round.

In the MotoGP class, Brad Binder took his first victory in the premier class, the first for a South African rider, the first non-European rider to win since Australian Jack Miller in the 2016 Dutch TT, as well the first rookie to win a Grand Prix since Marc Márquez in 2013.

Several Grands Prix were cancelled or postponed after the aborted opening round in Qatar, prompting the Fédération Internationale de Motocyclisme to draft a new calendar.

However, the Czech Republic Grand Prix was not impacted by this change and kept its original date.

[3] In Q1, Álex Rins set the fastest lap of the session with the factory KTM of Brad Binder 0.6 secs behind.