The 2020 Louisville Cardinals football team represented the University of Louisville during the 2020 NCAA Division I FBS football season.

This was the team's second season under head coach Scott Satterfield.

After compiling a 4–7 regular season record (3–7 in ACC play), Satterfield advised in mid-December that "we aren’t in line for a bowl" after Louisville's director of athletics conferred with ACC officials.

[1] Louisville had games scheduled against Kentucky, and Murray State, which were all canceled due to the COVID-19 pandemic.

The ACC released their schedule on July 29, with specific dates selected on August 6.