The Gamecocks played their home games at Williams–Brice Stadium in Columbia, South Carolina, and were led by head coach Will Muschamp until his firing on November 15.

[4] Home games were extremely regulated, limited to approximately 15,000 season ticket holders and a small number of other spectators, all required to wear masks.

[7][8] The Gamecocks were slated to play UAB, but had to withdraw on December 22 due to COVID-19 issues within the program.

[9] Sources: In the preseason media poll, South Carolina was predicted to finish in fifth place in the East Division.

[16] ‡ As part of their penalty for NCAA violations, Tennessee has retroactively vacated its 2020 victory over South Carolina.