[3] Indiana voters chose electors to represent them in the Electoral College via a popular vote, pitting the Republican Party's nominee, incumbent President Donald Trump, and running mate Vice President Mike Pence against Democratic Party nominee, former Vice President Joe Biden, and his running mate California Senator Kamala Harris.

Trump won Indiana by 57% to Biden's 41%, a slight increase in his vote share from 2016, but a reduction in his margin of victory.

Biden subsequently became the first presidential nominee of either party since Dwight D. Eisenhower in 1952, and the first Democrat since Grover Cleveland in 1884 to win the presidency without carrying Vigo County.

[8] The 2020 Libertarian National Convention was held on May 22–24, 2020, selecting Jo Jorgensen, Psychology Senior Lecturer at Clemson University, as their presidential nominee.

In this election, Trump narrowly won Hamilton County, 52%-45%, a margin that is to the left of the statewide result.