The 2021–22 3.
Liga (Slovakia) season was the 29th edition of the third tier [[3.
Liga (Slovakia) annual football competition since its establishment in 1993.
66 teams contested being divided into three geographic groups of 16 teams: 3. liga Bratislava, 3. liga Západ (West), 3. liga Stred (Central), 3. liga Východ (Eastern); except group (Západ) composed of 18 teams.
The following teams have changed division since the 2020–21 season: Relegated from 2. liga Promoted from 4. liga Promoted to 2. liga Relegated to 4. liga Relegated to 5. liga