The 2021–22 season was ŠK Slovan Bratislava's 16th consecutive in the top flight of Slovak football.

Subsequently, Slovan competed in this season's edition of the UEFA Europa League, but were eliminated in the play-off round.

As of 21 May 2022 Win Draw Loss As part of the pre-season preparation, the club announced it would complete two training camps.

[25] As part of the first block of the mid-season preparation, focused mainly on fitness, Slovan were to play one friendly match, but it was cancelled due to COVID-19 related issues.

[38] The draw for the group stage was held on 27 August 2021[39] with the fixtures announced on a day later.