In addition to the domestic league, Atlético Madrid participated in this season's editions of the Copa del Rey, the Supercopa de España, and the UEFA Champions League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[33][34] The draw for the group stage was held on 26 August 2021.