and the club's 64th consecutive season in the top flight of Turkish football.

In addition to the domestic league, Fenerbahçe participated in this season's editions of the Turkish Cup, the UEFA Europa League and the UEFA Europa Conference League.

Fenerbahçe's 2021–22 kits, manufactured by Puma, released on 9 July 2021 and were up for sale on the same day.

Win Draw Loss Fixtures Source: Soccerway Source: TFF.org Pld = Matches played; W = Matches won; D = Matches drawn; L = Matches lost; GF = Goals for; GA = Goals against; GD = Goal difference; Pts = Points The group stage draw was held on 27 August 2021.

The draw for the knockout round play-offs was held on 13 December 2021.