The 2021–22 II liga (also known as eWinner II liga due to sponsorship reasons) was the 74th season of the third tier domestic division in the Polish football league system since its establishment in 1948 and the 14th season of the Polish II liga under its current title.

[3] A total of 18 teams participate in the 2021–22 II liga season.

Note: The place taken by the team that played fewer matches than the opponents was underlined.

The winner of final match was promoted to the I liga for next season.

All matches was played in a stadiums of team which occupied higher position in regular season.