The 2021–22 season is New Basket Brindisi's 30th in existence and the club's 4th consecutive season in the top tier of Italian basketball.
Supplier: Adidas / Sponsor: Happy Casa Two captains were appointed for the season: Zanelli was the captain for the Serie A matches, while Chappell for the Champions League.
[1] Note: Flags indicate national team eligibility at FIBA-sanctioned events.
Players may hold other non-FIBA nationalities not displayed.
(colours: Italian or homegrown players; foreign players; young players)