The 2021–22 Old Dominion Monarchs women’s basketball team represented Old Dominion University during the 2021–22 NCAA Division I women's basketball season.

The team was led by second-year head coach DeLisha Milton-Jones, and played their home games at the Chartway Arena in Norfolk, Virginia as a member of Conference USA.

[1][2] On October 27, 2021, Old Dominion announced that this will be the last season for the team in the C-USA and become the Sun Belt Conference on July 1, 2022.