[7] The Hampton Coliseum is the home of the Virginia Duals annual wrestling tournament, hosting invitational college and high school matches.

The Grateful Dead performed 21 concerts at Hampton Coliseum between 1979 and 1992, including their now-famous 1989 shows at the venue.

[8][9] The world's first pay-per-view live broadcast of a rock show was held at the venue on December 18, 1981, when The Rolling Stones American Tour 1981 ended with a two-night stint.

[10] Other performers include: The Who, Bon Jovi, Led Zeppelin, Van Halen, Pretty Lights, Pink Floyd,[11] U2, Marvin Gaye, The Jacksons, Parliament-Funkadelic, Tina Turner, Bruce Springsteen, R.E.M.,[12] Dave Matthews Band, String Cheese Incident, Widespread Panic,[13] Jerry Garcia Band,[14] Pearl Jam, Griz, KISS, and Grateful Dead offshoots Furthur and The Other Ones.

The popularity of Hampton Coliseum among performers has led to the release of many notable live albums and tracks that were recorded at the venue.