The Orange are ninth year members of the Atlantic Coast Conference and played their home games at the Carrier Dome in Syracuse, New York.

Previous head coach Quentin Hillsman resigned amid investigations into allegations of inappropriate behavior on August 2, 2021.

As the twelfth seed in the ACC tournament, they lost to Clemson in their First Round matchup.

As the fifth seed in the ACC tournament, they defeated to Boston College in the Second Round and Florida State in the Quarterfinals before losing to Louisville in the Semifinals.

They received an at-large bid to the NCAA tournament where they were the eight seed in the Riverwalk Regional.