The 2021–22 Winthrop Eagles men's basketball team represented Winthrop University in the 2021–22 NCAA Division I men's basketball season.

The Eagles, led by first-year head coach Mark Prosser, played their home games at the Winthrop Coliseum in Rock Hill, South Carolina as members of the Big South Conference.

2 seed in the Big South tournament, they defeated High Point[3] and Gardner–Webb,[4] before falling to Longwood in the championship game.

[6] They defeated Campbell in the finals of the Big South tournament.

[7] They earned the Big South's automatic bid into the NCAA tournament and were defeated by Villanova in the first round.