On 31 May 2021, the league committee decreed the three groups would be split horizontally in geographical terms, from north to south.
rejected league application of Carpi, Casertana, Novara, Paganese and Sambenedettese.
[20] On 26 July 2021 the Italian National Olympic Committee admitted Paganese's reclaim.
On 9 April 2022, Catania was excluded from the league with immediate effect due to financial issues, with only four games left for them to play till the end of the regular season; all of the club's results were subsequently expunged.
As Padova and Südtirol, respectively winners and runners-up of the 2021–22 Coppa Italia Serie C, concluded the season in the first two spots from Group A, an additional spot in the national phase of the playoffs will be handed to the fourth-placed team from Group A itself.