The final was played at the Arena Kombëtare in Tirana, Albania,[3] with Roma defeating Feyenoord 1–0.

[8] A total of 181 teams from 54 of the 55 UEFA member associations participated in the 2021–22 UEFA Europa Conference League (the exception being Spain, as none of their teams finished third in the Europa League group stage).

[12] Apart from the allocation based on the country coefficients, associations could have additional teams participating in the Europa Conference League, as noted below: The following is the access list for this season.

The following changes were confirmed by UEFA:[14] Moreover, in the default access list, originally 17 losers from the Champions League first qualifying round were transferred to the Europa Conference League second qualifying round (Champions Path).

[25] Matches were scheduled for Thursdays apart from the final, which took place on a Wednesday, though exceptionally could take place on Tuesdays or Wednesdays due to scheduling conflicts (especially featuring teams from countries where there were very few sufficient stadiums, such as Gibraltar and Wales).

Scheduled kick-off times starting from the group stage were 18:45 (instead of 18:55 previously) and 21:00 CEST/CET, though exceptionally could take place at 16:30 due to geographical reasons.

On 16 July 2021, UEFA announced that the group stage draw would be held in Istanbul, Turkey.

The draw for the group stage was held on 27 August 2021, 13:30 CEST (14:30 TRT), in Istanbul, Turkey.

Alashkert, Bodø/Glimt, Flora, Kairat, Lincoln Red Imps, Mura, Randers and Union Berlin made their debut appearances in a UEFA competition group stage.

Alashkert, Flora and Lincoln Red Imps were the first teams from Armenia, Estonia and Gibraltar, respectively, to play in a UEFA competition group stage.

In the knockout phase, teams played against each other over two legs on a home-and-away basis, except for the one-match final.

The UEFA technical study group selected the following players as the team of the tournament.