FitzGerald Tennis Center in Washington, D.C., United States, from July 31 to August 8, 2021.

[4] After the Citi Open returned in 2021 from the event's eventual cancellation in the prior year,[5] the WTA stayed its revocation of the event's sanction, so the women's tournament did not return as many women's players had scheduling conflicts with the 2020 Summer Olympics.

[6] In its place, event officials created the inaugural women's invitational as a three-day exhibition during the US Open Series.

[9][10] Azarenka was scheduled to play Pegula the following day, after Brady withdrew from the tournament, to decide the final match, but Azarenka herself later withdrew from the invitational after suffering an ankle injury.

[12] On August 7, Pegula defeated Gauff in the final match, 4–6, 7–5, [10-8], to win the invitational.