The 2021 East Carolina Pirates football team represented East Carolina University in the 2021 NCAA Division I FBS football season.

The Pirates, led by third-year head coach Mike Houston, play their home games at Dowdy–Ficklen Stadium as members of the American Athletic Conference.

After compiling a 7–5 regular season record, the Pirates received a bid to the Military Bowl,[1] where they were due to face the Boston College Eagles.

On December 26, the Eagles withdrew from the game, due to COVID-19 issues; the bowl was subsequently canceled.

[4] at Dowdy-Ficklen Stadium • Greenville, North Carolina