The 2021 South Florida Bulls football team represented the University of South Florida (USF) during the 2021 NCAA Division I FBS football season.

The Bulls were led by second-year head coach Jeff Scott and played their home games at Raymond James Stadium in Tampa, Florida.

This season was the ninth for the Bulls as members of the American Athletic Conference and 25th season overall.

The American Athletic Conference preseason media poll was released at the virtual media day held August 4, 2021.

[1] Cincinnati, who finished the 2020 season ranked No.