The 2021 Memphis Tigers football team represented the University of Memphis in the 2021 NCAA Division I FBS football season.

The Tigers played their home games at Liberty Bowl Memorial Stadium in Memphis, Tennessee, and competed in the American Athletic Conference.

They were led by second-year head coach Ryan Silverfield.

The Tigers finished the regular season with a 6–6 record and were due to face the Hawaii Rainbow Warriors in the Hawaii Bowl.

However, due to a COVID-19 outbreak, season-ending injuries, and transfers, the Rainbow Warriors were forced to withdraw the day before the game, leaving the Tigers without a bowl game.