The club finished with a league worst 4–15–4 record in their second MLS season in 2020, one shortened by the COVID-19 pandemic in Ohio.

The season was the first year that FC Cincinnati played home matches at newly built TQL Stadium.

FC Cincinnati's offseason transfers were executed under general manager Gerard Nijkamp and head coach Jaap Stam.

On August 6, 2021, Nijkamp and the club mutually agreed to part ways.

Win Draw Loss Numbers after plus-sign(+) denote appearances as a substitute.