The 2021 FIBA Under-16 Women's Americas Championship was an international basketball competition held in León, Guanajuato, Mexico, from 23 to 29 August 2021.

[1] It was the seventh edition of the FIBA Under-16 Women's Americas Championship.

The top four teams qualified for the 2022 FIBA Under-17 Women's Basketball World Cup in Hungary.

Eight teams from three sub zones were qualified through the Nike Youth Ranking for each sub-zone.

[2] The draw ceremony for the competition took place on 10 August at the FIBA Regional Office, in the city of Miami, Florida.