The 2021 Festival Luxembourgeois du cyclisme féminin Elsy Jacobs (known as the Ceratizit Festival Elsy Jacobs for sponsorship reasons) was a women's road cycling stage race that was held in Luxembourg from 30 April to 2 May 2021.

It was the 13th edition of the Festival Elsy Jacobs and the first as a category 2.Pro event in the UCI Women's ProSeries after its promotion after the 2019 season and the cancellation of the 2020 edition of the race.

[1] Eight of the nine UCI Women's WorldTeams and ten UCI Women's Continental Teams made up the eighteen teams that participated the race.

Each team entered a full squad of six riders, but two Alé BTC Ljubljana riders had to pull out prior to the start of the race.

[2][3] This left 106 riders who started the race, of which 67 finished.