2021 Hamburg European Open – Men's singles

Andrey Rublev was the defending champion,[1] but chose to not defend his title as he and other Russian Olympic athletes were sent to Yuzhno-Sakhalinsk for training sessions.

[2] Pablo Carreño Busta won his maiden ATP Tour 500 singles title, defeating Filip Krajinović in the final, 6–2, 6–4.

The top four seeds received a bye into the second round.