The Cardinals played their home games at Gayle and Tom Benson Stadium in San Antonio, Texas.

On November 12, 2021, Incarnate Word announced that this will be the last season for the team in the Southland and will then join the Western Athletic Conference on July 1, 2022.

However, UIW announced they would remain in the Southland in late June and would not join the WAC.

[3][4] Source:[5] Source:[6] Quarterback Running back Wide receiver Tight end Offensive line Defensive line Kicker Punter Linebacker Defensive back Long snapper Legend

The following Cardinals received postseason honors for the 2021 season:[7] Associated Press FCS All-American Second–Team WR Taylor Grimes – Junior Associated Press FCS All-American Third–Team LB Kelechi Anyalebechi – Senior Stats Perform FCS All-American Second–Team QB Cam Ward – Sophomore WR Taylor Grimes – Junior Stats Perform FCS All-American Third–Team LB Kelechi Anyalebechi – Senior HERO Sports FCS All-American Second–Team WR Taylor Grimes – Junior Southland Conference Offensive Player of the Year QB Cameron Ward – Sophomore Southland Conference Coach of the Year Eric Morris All–Southland Conference First–Team RB Kevin Brown – Graduate Senior WR Taylor Grimes – Junior OL Nash Jones – Sophomore DL Cameron Preston – Senior LB Kelechi Anyalebechi – Senior DB Kaleb Culp – Sophomore PR Robert Ferrel – Senior