The league, due to COVID-19 pandemic travel restrictions, consisted of a total of eighteen short course swimming meets, called matches, spanning four stages of competition and held in two locations.

The France-based Energy Standard won the Final Match, with the Most Valuable Player award going to Sarah Sjöström of the same team.

[2] The schedule consisted of eleven regular season and play in meets in Naples,[3] followed by six Semifinals and the Final Match in Eindhoven.

The top two finishers of the second edition of the league, Cali Condors and Energy Standard, did not compete against each other during any regular season match.

The following world records were set as a part of competition during the 2021 International Swimming League.