The 2021 Memphis 901 FC season was the third season for Memphis 901 FC in the USL Championship, the second-tier professional soccer league in the United States and Canada.

[1] This article covers the period from November 2, 2020 (the day after the ultimately cancelled 2020 USLC playoffs final) to the end of the 2021 USLC season (tentatively scheduled for November 2021).

The 2021 USL Championship season schedule for the club was announced on December 19, 2018.

The format included just four teams from the USL Championship, the four semi-finalists from the 2020 playoffs (El Paso, Louisville, Phoenix, and Tampa).

Due to the fact that Memphis failed to qualify for the 2020 USLC playoffs, this eliminated the club from the 2021 U.S. Open Cup.