They also became the sixth team in NFL history to win four or more consecutive games after losing seven in a row, after the 2009 Cleveland Browns, 1994 New York Giants, 1993 New England Patriots, 1984 Green Bay Packers, and the 1978 St. Louis Cardinals.

However in a surprise move and due to alleged conflicts with both the roster and front office, owner Stephen M. Ross dismissed head coach Brian Flores on January 10, 2022.

[4] On February 2, the Dolphins announced coaches Eric Studesville and George Godsey would share the offensive coordinator position for the upcoming 2021 season.

[8] Atlanta Falcons' head coach Arthur Smith announced his team would hold joint practices with the Miami Dolphins sometime around August 21 at Hard Rock Stadium.

[9] On July 27, 2021, All-Pro cornerback Xavien Howard officially requested a trade from the Dolphins over a months-long contract dispute.

The win was secured when Damien Harris fumbled the ball with 3:35 left in the fourth quarter and Miami ran out the clock.

Despite forcing two turnovers to extend their streak of games with takeaways to 24, the Dolphins suffered their worst loss to the Bills with a 35–0 shutout by Buffalo.

Quarterback Tua Tagovailoa suffered a rib injury in the first quarter, forcing backup Jacoby Brissett to finish the game in his stead.

Tannehill had played for the Dolphins from 2012–2018 as their primary starter aside from missing the 2017 season due a torn ACL he suffered during the preseason that year.

The Dolphins' seven-game win streak was snapped by the 34–3 loss and failed to win 8 games in a row for the first time since 1984; because of this and the Buffalo Bills beating and eliminating the Atlanta Falcons and clinching playoff berth, the New England Patriots blowing out the Jacksonville Jaguars and clinching playoff berth, the Las Vegas Raiders beating the Indianapolis Colts, and the Los Angeles Chargers beating the Denver Broncos, the Dolphins missed the playoffs for the fifth season in a row.

[2] Additionally, the Chargers win also crushed all playoff hopes for the Denver Broncos, as well as the Cleveland Browns, who were scheduled to kick off Sunday Night Football later that evening.

With the win, the Dolphins finished the season with a record of 9–8, but head coach Brian Flores was dismissed the next day.