The 2021 Mississippi State Bulldogs football team represented Mississippi State University in the 2021 NCAA Division I FBS football season.

The Bulldogs played their home games at Davis Wade Stadium in Starkville, Mississippi, and competed in the Western Division of the Southeastern Conference (SEC).

They were led by second-year head coach Mike Leach.

[1] In the preseason media poll, Mississippi State was predicted to finish last in the West Division.

Mississippi State had two players selected in the 2022 NFL draft.