The 2021 Tennessee State Tigers football team represented Tennessee State University during the 2021 NCAA Division I FCS football season as a member of the Ohio Valley Conference (OVC).

They were led by first-year head coach Eddie George and played their games at Nissan Stadium in Nashville, Tennessee.

On April 12, 2021, Southern University announced that Rod Reed would not return as head coach.

[3] Source:[4] at Pro Football Hall of Fame Fieldhouse, Canton, OH

This college football 2020s season article is a stub.