The 2021 Murray River Open was a tournament on the 2021 ATP Tour.

It was played on outdoor hard courts in Melbourne, Australia.

It was organised as a lead-up tournament to the 2021 Australian Open, and was held at the same venue, due to other tournaments in Australia being cancelled as a result from the COVID-19 pandemic.

This tournament took place simultaneously with the 2021 Great Ocean Road Open and the 2021 ATP Cup.

*per team The following players received wildcards into the main draw: The following players have been accepted directly into the main draw using a protected or a special ranking: The following player received entry as an alternate: The following pairs received wildcards into the doubles main draw: The following pair received entry using a protected ranking: