The 2021 NCAA Division II football season, part of college football in the United States organized by the National Collegiate Athletic Association (NCAA) at the Division II level, began on August 28 and ended December 18 with the Division II championship at the McKinney Independent School District Stadium in McKinney, Texas.
Ferris State defeated Valdosta State, 58–17, for the title.
September 3: Southern Connecticut 28, Central Connecticut 21 September 4: West Florida 42, McNeese State 36 Teams that advanced to the semifinals were re-seeded.