The 2021 New Mexico State Aggies football team represented New Mexico State University as an independent during the 2021 NCAA Division I FBS football season.

Led by Doug Martin in his ninth and final season as head coach, the Aggies compiled a record of 2–10.

New Mexico State played home games at Aggie Memorial Stadium in Las Cruces, New Mexico.

On November 28, the day following the Aggies' season finale, athletic director Mario Moccia announced that Martin's contract would not be renewed.

Martin finished his career at New Mexico State with an overall record of 25–74 through nine seasons.