He attended Cardinal Ritter College Prep High School and played for their football team.

In the 2021 Sugar Bowl, Williams scored a touchdown on a 45-yard reception against Clemson in the College Football Playoffs Semifinal.

[16] He made an instant impact with four receptions for 126 receiving yards and one touchdown in a 44–13 victory over Miami in the Chick-fil-A Kickoff Game.

[25][26] Williams suffered a torn ACL in the 2022 College Football Playoff National Championship rematch with Georgia.

[33] He was placed on the reserve/non-football injury list to start the season on August 23, 2022, due to the torn ACL suffered in college.

[37] The next week, his first career reception was a 41-yard receiving touchdown, contributing to a 34–23 victory over the same Minnesota Vikings team who traded his pick away.

[39] Williams was one of four Lions players suspended for violating the NFL's gambling policy after an investigation by the league.

Cephus and Moore were suspended indefinitely for betting on NFL games, as was Washington Commanders defensive end Shaka Toney.

[44] In Week 6 against the Tampa Bay Buccaneers, Williams caught two of his three targets for 53 yards, which included a 45-yard touchdown catch.

[47] In Week One against the Los Angeles Rams, Williams caught a career-high five passes for 121 yards and one touchdown.

[52] In the Divisional Round game against the Washington Commanders, Williams rushed for a 61-yard touchdown, made one 19-yard reception, and threw one interception, ultimately ending in a 31–45 loss.