The Liberty opened the regular season on May 14, 2021 versus the Indiana Fever.
However, June turned into a much worse month for the team as wins were book-ended by two losses.
The post-Olympic break stretch of the season proved difficult for the Liberty.
Going into the last game of the season, the Liberty were part of a three way tie for the eighth, and final playoff seed.
The Liberty defeated Washington and Los Angeles lost their final game, so the Liberty won the tiebreaker and qualified for the playoffs as the eighth seed with a final record of 12–20.