The 2021 Northern Colorado Bears football team represented the University of Northern Colorado as a member of the Big Sky Conference during the 2021 NCAA Division I FCS football season.

They were led by first-year head coach Ed McCaffrey and played their home games at Nottingham Field.

On July 26, 2021, during the virtual Big Sky Kickoff, the Mustangs were predicted to finish in the Big Sky last in the media and twelfth in the coaches.

[1] The Bears did not have any players selected to the preseason all-Big Sky team.

This college football 2020s season article is a stub.