The 2021 Northwestern State Lady Demons softball team represented Northwestern State University during the 2021 NCAA Division I softball season.

The Lady Demons played their home games at Lady Demon Diamond and were led by thirteenth year head coach Donald Pickett.

The Southland Conference Coaches Poll was released on February 5, 2021.

Northwestern State was picked to finish sixth in the Southland Conference with 156 votes and 1 first place vote.

[2] [3] [4] Pitchers Outfielders Catchers Infielders Utilities All Conference First Team