The 2021 Incarnate Word Cardinals softball team represented the University of the Incarnate Word during the 2021 NCAA Division I softball season.

The Cardinals played their home games at H-E-B Field and were led by fourth-year head coach Joe DiPietro.

The Southland Conference Coaches Poll was released on February 5, 2021.

Incarnate Word was picked to finish dead last in the Southland Conference at twelfth with 32 votes.

[2] No players from Incarnate Word were chosen to the All-Southland team [3] Pitchers Outfielders Catchers Infielders Utility *Rankings are based on the team's current ranking in the NFCA/USA Softball poll.