[1] Wales (consisting of players Gerwyn Price and Jonny Clayton) were the defending champions, after beating the English team (Michael Smith and Rob Cross) 3–0 in the 2020 final.

Scotland went on to win their second title after beating Austria, represented by Mensur Suljović and Rowby-John Rodriguez, in the final 3–1.

Peter Wright revealed on September 4 that Gary Anderson would not be representing Scotland for personal reasons and that John Henderson would replace him, while Danny Baggish also had to withdraw from the United States team due to quarantine regulations, with Chuck Puleo replacing him.

[9] New Zealand (who were to be represented by Warren Parry and Ben Robb) missed out for the first time owing to their country's COVID travel restrictions, and after a confusion by an incorrect communication sent by PDC Nordic & Baltic, it was revealed that the Latvian team of Madars Razma and Nauris Gleglu would be the first reserves, and not one of the 32 teams in the competition.

Paolo Nebrida was due to represent the Philippines, but had to withdraw as his COVID-19 vaccination was not on the approved list to get him into Germany, so he was replaced by Christian Perez.

Russia's Dmitriy Gorbunov also had to withdraw to due quarantine regulations and was replaced by Evgenii Izotov.