The tournament took place from 26–28 November 2021 at the Butlin's Resort, Minehead, returning to its usual venue after being held behind closed doors at the Ricoh Arena in Coventry in 2020.

Michael van Gerwen was the two-time defending champion after defeating Mervyn King 11–10 in the 2020 final,[1] but lost to Peter Wright at the quarter-final stage.

Wright went on to win the tournament for the first time, defeating Ryan Searle 11–10 in the final.

[2] The 2021 Players Championship Finals had a total prize fund of £500,000, the same amount that was available in 2019 and 2020.

[4] On 23 November, it was announced that Jamie Hughes was forced to withdraw after testing positive for COVID-19.